Symphony is a technology driven organization with flexible approach, in-depth synthetic chemistry skills, analytical competency and expertise in medicinal chemistry, process research, process optimization, process validation, scale-up and large scale manufacturing to support customer’s NCE and API development programs.

Symphony has dynamic team of professionals with brilliant scientific skills, project management capabilities and hands on experience to handle NCEs and regulatory requirements upholding confidentiality and safety standards. It has excellent technical capabilities to deliver diverse chemistries from R&D to commercial scale and provides high quality cost effective support to drug discovery, CMC, clinical and generic programs to Pharmaceutical and Biotech companies.

The team has shaped up track record of delivering couple of NCE Projects to his customer in a record time, right from the conceptual stage to multi-kilo scale. Likewise, there are many significant achievements in this short span leading to customer delight and satisfaction.

Services.... CRAMS

• Contract Research … FTE
• Custom Synthesis
• Contract Manufacturing

Project Profile

• Pre-clinical and clinical supply of NCEs and its Intermediates
• Process research/ improvement/validations
• Non infringing route development
• Medicinal chemistry.. Libraries/Analogues
• API development
• Intermediates
• Key starting materials
• Multi-step synthesis / Building blocks
• Impurities/ Reference standards
• Analytical method development and validations

Building Blocks and Intermediates

• Bicyclo compounds
• Thiophenes
• Quinoxalines
• Pyrazoles
• Imidazoles
• Pyridines
• Miscellaneous

Technologies

Organo-mettallic Chemistry

• n-BuLi handling
• LDA handling
• Grignard reaction

Hazardous Chemistry

• Cyanation
• Nitration
• LAH reaction
• AlCl3 handling
• Sodium metal/hydride/Azide handling
• Bromination/ Chlorination (POCl3, PCl5, SOCl2, Cl2, Br2, HBr)

Coupling Reactions

• Suzuki coupling
• Heck coupling
• Sonogashira coupling
• Amide coupling (DCC, EDC.HCl etc)

Specialized Chemistry

• Multi-step synthesis
• Carbohydrate chemistry
• Cryogenic reactions (-70°C)
• Heterocyclic chemistry
• Polymorphic study : Crystallization/Salt formation

Miscellaneous

• Cyclization
• Hydrogenation/ Dehydrogenation
• Chiral Chemistry
• Friedel-craft reactions
• Column chromatography
• High vacuum distillations
• Alkylation
• Diazotization
• Sulfonation (ClSO3H, MeSO2Cl)